Cell Signalling

Research team members

Mgr. Pavel Krejčí, Ph.D.

Group leader

phone: +420 549 49 5395
e‑mail:
Graduate students

Iva Gudernova
Neha Basheer
Alexandru Nita
Marketa Tomanova
Tomas Gregor
Sara P. Abraham

Technicians

Vladimira Hykelova
Jitka Krenova

About our research

The major focus of our research for over 15 years has been to dissect the mechanisms of fibroblast growth factor (FGF) signaling. We are interested in pathological FGF-receptor (FGFR) signaling in disease, namely the skeletal disorders caused by activating mutations in FGFR3 (hypochondroplasia, achondroplasia, thanatophoric dysplasia, SADDAN). Our studies encompass many different areas of the FGF field including expression of FGF ligands in vivo, mechanisms of FGF/FGFR-mediated regulation of cell function, molecular mechanisms of FGFR signal transduction, biochemistry of FGFR kinase activation, development of FGFR inhibitors, and others. In our research, we actively collaborate with other scientists worldwide, including those from Norway (Dr. A. Wiedlocha, Oslo University), USA (Dr. D. Krakow, University of California Los Angeles; Dr. K. Hristova, John Hopkins University, Baltimore) and the Czech Republic (Dr. L. Trantirek, Masaryk University CEITEC, Brno; Dr. P. Konik, University of South Bohemia, Ceske Budejovice; Dr. M. Buchtova, Masaryk University).

more about research

3 PhD positions are available on the following topics:
  1. Non-canonical signaling of human receptor tyrosine kinases
    Neobvyklé signální dráhy lidských receptorových tyrozinových kináz 
  2. Mouse model for determination of precise spatiotemporal RTK/ERK signaling activity
    Vývoj myšího modelu pro přesné určení místa, míry a délky RTK/ERK signalizace
  3. Regulation of primary cilia by cellular kinases
    Regulace primárního cília buněčnými kinázami

HOW TO APPLY