Sara P. Abrahams
About our research
The major focus of our research for over 15 years has been to dissect the mechanisms of fibroblast growth factor (FGF) signaling. We are interested in pathological FGF-receptor (FGFR) signaling in disease, namely the skeletal disorders caused by activating mutations in FGFR3 (hypochondroplasia, achondroplasia, thanatophoric dysplasia, SADDAN). Our studies encompass many different areas of the FGF field including expression of FGF ligands in vivo, mechanisms of FGF/FGFR-mediated regulation of cell function, molecular mechanisms of FGFR signal transduction, biochemistry of FGFR kinase activation, development of FGFR inhibitors, and others. In our research, we actively collaborate with other scientists worldwide, including those from Norway (Dr. A. Wiedlocha, Oslo University), USA (Dr. D. Krakow, University of California Los Angeles; Dr. K. Hristova, John Hopkins University, Baltimore) and the Czech Republic (Dr. L. Trantirek, Masaryk University CEITEC, Brno; Dr. P. Konik, University of South Bohemia, Ceske Budejovice; Dr. M. Buchtova, Masaryk University).