Recombination and DNA Repair
Research team members
Raghib Ashraf, M.Sc.
Michaela Pospíšilová, Mgr.
Jan Zálešák, Mgr.
Jakub Cibulka, Mgr.
Veronika Weisová, Mgr.
Barbora Baránková, Mgr.
Petra Lysáková, Mgr.
About our research
DNA double-strand breaks (DSB) are among the most lethal forms of DNA damage. DSBs are induced by a large number of endogenous and exogenous agents, as genotoxic chemicals and ionizing radiation, or due to replication of damaged DNA as well as collapse of a replication fork. DSB can either be properly repaired, restoring genomic integrity, or miss-repaired resulting in cell death, genomic instability, and cancer.
Our group focuses on mechanisms of DSB repair using multi-disciplinary approach (biochemical, structural, computational, genetic, and single-molecule).
Laboratory of Recombination and DNA Repair (LORD)
Our laboratory focuses on molecular understanding of recombination and DNA repair processes. Using biochemical, structural, microscopic, bioinformatics, single/molecule and genetic approaches we wish to shed light onto mutation avoidance and development of cancer. Candidate can choose from many competitive projects (study of BRCA2 protein, Rothmund-Thomson syndrome helicase, Fanconi anemia proteins, Rad50/Mre11/Xrs2 complex, Srs2 helicase, DNA repair synthesis, Spo11 and meiotic breaks, role of structure specific nucleases etc.) Work in the team of young motivated people at the new campus of Masaryk University, financial bonus awarded every half a year, possibility of study stay at the laboratories of our collaborators.
Our research topics
Currently, our main research focus comprises these topics:
- Inhibitors of nucleases
- RAD51 and its paralogs
Up to two PhD positions are available on the following PhD research project
Our laboratory is also part of Project: Centrum výzkumu pluripotentních buněk a nestability genomu – PLURICELL CZ.1.07/2.3.00/20.0011