Publications

2023

Lenka Besse, Marianne Kraus, Andrej Besse , Christoph Driessen, Ignazio Tarantino. The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma. 2023. Sci Rep. doi: 10.1038/s41598-023-31400-6.

Xiang Zhou, Andrej Besse, Jessica Peter, Maximilian Johannes Steinhardt, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Xianghui Xiao, Hannah Hornburger, Larissa Haertle, Max Mendez Lopez, Umair Munawar, Angela Riedel, Seungbin Han, Elmer Maurits, Herman S Overkleeft, Bogdan Florea, Hermann Einsele, K Martin Kortüm, Christoph Driessen, Lenka Besse, Leo Rasche. High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to lowdose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex. 2023. Haematologica. doi:10.3324/haematol.2022.282225.

2022

Jonas Schwestermann, Andrej Besse, Christoph Driessen, Lenka Besse. Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors. 2023. Front Oncol. doi: 10.3389/fonc.2022.899272.

Ian D Ferguson, Bonell Patiño-Escobar, Sami T Tuomivaara, Yu-Hsiu T Lin, Matthew A Nix, Kevin K Leung, Corynn Kasap, Emilio Ramos, Wilson Nieves Vasquez, Alexis Talbot, Martina Hale, Akul Naik, Audrey Kishishita, Priya Choudhry , Antonia Lopez-Girona, Weili Miao, Sandy W Wong, Jeffrey L Wolf, Thomas G Martin 3rd, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, Avery D Posey Jr, R Dyche Mullins, Justin Eyquem, James A Wells, Arun P Wiita. The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. 2023. Nat Commun. doi: 10.1038/s41467-022-31810-6.

Andrej Besse, Marianne Kraus, Max Mendez-Lopez, Elmer Maurits, Herman S Overkleeft, Christoph Driessen, Lenka Besse. Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors. 2023. Cells. doi: 10.3390/cells11050838.

2021

Ian D. Ferguson, Bonell Patiño Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix, Kevin K. Leung, Martina Hale, Priya Choudhry, Antonia Lopez-Girona, Emilio Ramos, Sandy W. Wong, Jeffrey L. Wolf, Thomas G. Martin III, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, James A. Wells, Arun P. Wiita. Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance. 2021. bioRxiv. doi: 10.1101/2021.01.17.427038

Arnold Bolomsky, Juho J Miettinen, Alina Malyutina, Andrej Besse, Julia Huber, Stefanie Fellinger, Helene Breid, Alun Parsons, Kristaps Klavins, J Thomas Hannich, Stefan Kubicek, Jo Caers, Wolfgang Hübl, Martin Schreder, Niklas Zojer, Christoph Driessen, Jing Tang, Lenka Besse, Caroline A Heckman, Heinz Ludwig. Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma. 2021. Blood Adv. doi: 10.1182/bloodadvances.2020003826.

Konstantin Byrgazov, Andrej Besse, Marianne Kraus, Ana Slipicevic, Fredrik Lehmann, Christoph Driessen, Lenka Besse. Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells. 2021. Hemasphere. doi: 10.1097/HS9.0000000000000602.

Lenka Besse, Andrej Besse, Sara C Stolze, Amin Sobh, Esther A Zaal, Alwin J van der Ham, Mario Ruiz, Santosh Phuyal, Lorina Büchler, Marc Sathianathan, Bogdan I Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J Thomas Hannich, Alex Loguinov, Bart Everts, Celia R Berkers, Marc Pilon, Hesso Farhan, Christopher D Vulpe, Herman S Overkleeft, Christoph Driessen. Treatment with HIV-protease inhibitor nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple myeloma. 2021. Cancer Res. doi: 10.1158/0008-5472.CAN-20-3323.

Konstantin Byrgazov, Marianne Kraus, Andrej Besse, Ana Slipicevic, Fredrik Lehmann, Christoph Driessen, Lenka Besse. Up-regulation of multidrug resistance protein MDR1/ABCB1 in carfilzomib-resistant multiple myeloma differentially affects efficacy of anti-myeloma drugs. 2021. Leuk Res. doi: 10.1016/j.leukres.2020.106499.

Lenka Besse, Andrej Besse, Marianne Kraus, Elmer Maurits, Herman S Overkleeft, Beat Bornhauser, Jean-Pierre Bourquin, Christoph Driessen. High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors. 2021. Cells. doi: 10.3390/cells10112853.

To see publications in previous years, please use the following ORCID link.