Nicola Silva group: Meiotic DNA repair and Genome Stability




Velkova, M., Silva, N., Dello Stritto, M.R., Schleiffer, A., Barraud, P., Hartl, M., Jantsch, V.      „Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.” 2021, PLoS Genetics. doi:10.1371/journal.pgen.1009663.


Janisiw, E., Raices, M., Balmir, F., Paulin, F.L., Baudrimont, A., Von Haeseler, A., Yanowitz, L., Jantsch, V., Silva, N.Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity. 2020, Nature Communications. doi:10.1038/s41467-020-18693-1.

Germoglio, M., Valenti, A., Gallo, I., Forenza Ch., Santonicola, P., Silva, N., Adamo, A. „In vivo analysis of FANCD2 recruitment at meiotic DNA breaks in Caenorhabditis elegans.” 2020, Scientific reports. doi:10.1038/s41598-019-57096-1.


Janisiw, E., Dello Stritto, M.R., Jantsch, V., Silva, N.BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis.” 2018, PLoS Genetics. doi: 1371/journal.pgen.1007653

Nguyen, H., Labella, S., Silva, N., Jantsch, V., Zetka, M. “ elegans ZHP-4 is required at distinct steps in the formation of crossovers and their transition to segregation competent chias mata.” 2018, PLoS Genetics. doi: 10.1371/journal.pgen.1007776

Hong, , Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. and Gartner, A. „The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans.” 2018, PLoS Genetics. doi: 10.1371/journal.pgen.1007453.

Silva, N.* and Jantsch, V.* “UNC-84: LINC-ing chromosome movement and double strand break repair.” 2016, Journal of Cell Biology. org/10.1083/jcb.201604112 (*Co-corresponding authors).


Daryabeigi, A., Woglar, A., Baudrimont, A., Silva, N., Paouneskou, D., Vesely, C., Rauter, M., Penkner, A., Jantsch, M., Jantsch, V. “Nuclear Envelope Retention of LINC Complexes Is Promoted by SUN-1 Oligomerization in the Caenorhabditis elegans Germ Line.” 2016, Genetics. doi: 10.1534/genetics.116.188094.

Crawley, O., Barroso, C., Testori, S., Ferrandiz, N., Silva, N., Castellano-Pozo, M., Jaso-Tamame, A.L., Martinez-Perez, E. “Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes.” 2016, doi: 10.7554/eLife.10851.


Silva, , Ferrandiz, N., Barroso, C., Tognetti, S., Lightfoot, J., Telecan, O., Encheva, V.,Faull, P., Hanni, S., Furger, A., Snidjers, A. P., Speck, C., Martinez-Perez, E. “The fidelity of synaptonemal complex assembly is regulated by a signalling mechanism that controls early meiotic progression.” 2014, Developmental Cell. 4:503-511.

Weick, E.-M.*, Sarkies, P.*, Silva, N., Chen, R.A., Moss, S.M., Cording, A.C., Ahringer, J., Martinez- Perez E., and Miska, E.A. “PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif- dependent piRNAs in C. elegans.” 2014, Genes & Development. 28: 783-796. (*Equal contribution)


Silva N., Adamo, A., Santonicola, P., Martinez-Perez E., and La Volpe, A. “Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.” 2013, Cell Death & Differentiation. 20: 1209–1218.


Adamo, A., Woglar, A., Silva, N., Penkner, A., Jantsch, V., and La Volpe, A. “Transgene-mediated co-suppression and RNA interference enhance germline apoptosis in Caenorhabditis elegans.” 2012, Proceeding of the National Academy of Sciences. 9: 3440–3445.


Adamo, A.*, Collis, S.J.*, Adelman, C.A., Silva, N., Horejsi, Z., Ward, J.D., Martinez-Perez, E., Boulton, J., La Volpe, A. “Preventing non-homologous end joining suppresses DNA repair defects of Fanconi anemia.” 2010, Molecular Cell. 39: 25–35. (*Equal contribution)


Adamo, A.*, Montemauri, P.*, Silva, N., Ward, J.D., Boulton, S.J. and La Volpe, A. “BRC-1 acts in the inter-sister pathway of meiotic DSB ” 2008, EMBO Reports. 39: 25–35. (*Equal contribution)

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