Publications

2025

MENDEZ-LOPEZ, Max, Andrej BEŠŠE, Christian ZUPPINGER, Christian PEREZ-SHIBAYAMA, Cristina GIL-CRUZ, Bogdan I. FLOREA, De Martin ANGELINA, Mechthild LUTGE, Deborah BECKEROVÁ, Šimon VRANA, Xiang ZHOU, Leo RASCHE, Jan PŘIBYL, Vladimír ROTREKL, Burkhard LUDEWIG, Herman S. OVERKLEEFT, Lenka BEŠŠE, Christoph DRIESSEN. Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system. ISCIENCE, 2025, roč. 28. ISSN 2589-0042. doi: 10.1016/j.isci.2025.113228.

SVĚRÁK, Filip, Daniil KABANOV, Šimon VRANA, Deborah BECKEROVÁ, Jan MÁCHAL, Martin PEŠL, Vladimír ROTREKL, Jan PŘIBYL. Dual-Organoid Biosensor for Monitoring Cardiac Conduction Disturbances In Vitro. ANALYTICA CHIMICA ACTA, 2025, roč. 2025. ISSN 0003-2670. doi: 10.1016/j.aca.2025.344874.

FOJTÍK, Petr, Martin ŠENFLUK, Kateřina HOLOMKOVÁ, Anton SALYKIN, Jana GREGOROVÁ, Pavel ŠMAK, Ondřej PEŠ, Jan RAŠKA, Deborah BECKEROVÁ, Monika ŠTĚTKOVÁ, Petr SKLÁDAL, Miroslava SEDLÁČKOVÁ, Aleš HAMPL, Dáša BOHAČIAKOVÁ, Stjepan ULDRIJAN, Vladimír ROTREKL. FGF2 supports NANOG expression via pyruvate dehydrogenase-dependent histone acetylation under low oxygen conditions. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2025, roč. 13. ISSN 2296-634X. doi: 10.3389/fcell.2025.1623814.

2024

DE LA BOURDONNAYE, Gabin, Tereza GHAZALOVÁ, Petr FOJTÍK, Kateřina KUTÁLKOVÁ, David BEDNÁŘ, Jiří DAMBORSKÝ, Vladimír ROTREKL, Veronika ŠTĚPÁNKOVÁ, Radka CHALOUPKOVÁ. Computer-aided engineering of stabilized fibroblast growth factor 21. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2024, roč. 23. ISSN 2001-0370. doi: 10.1016/j.csbj.2024.02.001.

KLIMOVIČ, Šimon, Deborah BECKEROVÁ, Jakub VĚŽNÍK, Daniil KABANOV, Karel LACINA, Šárka JELÍNKOVÁ, Jaromír GUMULEC, Vladimír ROTREKL, Jan PŘIBYL. Hyaluronic acid-based hydrogels with tunable mechanics improved structural and contractile properties of cells. BIOMATERIALS ADVANCES, 2024, roč. 159. ISSN 2772-9508. doi: 10.1016/j.bioadv.2024.213819.

KABANOV, Daniil, Šimon VRANA, Deborah BECKEROVÁ, Martin MOLČAN, Martin ŠČUREK, Kristián BRAT, Markéta BÉBAROVÁ, Vladimír ROTREKL, Jan PŘIBYL, Martin PEŠL. Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model. SCIENTIFIC REPORTS, 2024, roč. 14. ISSN 2045-2322. doi: 10.1038/s41598-024-76846-4.

2023

KOHUTOVÁ, Aneta, Dita MÜNZOVÁ, Martin PEŠL, Vladimír ROTREKL. α(1)-Adrenoceptor agonist methoxamine inhibits base excision repair via inhibition of apurinic/apyrimidinic endonuclease 1 (APE1). ACTA PHARMACEUTICA, 2023, roč. 73. ISSN 1330-0075. doi: 10.2478/acph-2023-0012.

2022

KLIMOVIČ, Šimon, Martin ŠČUREK, Martin PEŠL, Deborah BECKEROVÁ, Šárka JELÍNKOVÁ, Tomáš URBAN, Daniil KABANOV, Zdeněk STÁREK, Markéta BÉBAROVÁ, Jan PŘIBYL, Vladimír ROTREKL, Kristián BRAT. Aminophylline Induces Two Types of Arrhythmic Events in Human Pluripotent Stem Cell–Derived Cardiomyocytes. FRONTIERS IN PHARMACOLOGY, 2022, roč. 12. ISSN 1663-9812. doi: 10.3389/fphar.2021.789730.

KABANOV, Daniil, Šimon KLIMOVIČ, Vladimír ROTREKL, Martin PEŠL, Jan PŘIBYL. Atomic Force Spectroscopy is a promising tool to study contractile properties of cardiac cells. MICRON, 2022, roč. 155. ISSN 0968-4328. doi: 10.1016/j.micron.2021.103199.

PIVATO, Roberto, Šimon KLIMOVIČ, Daniil KABANOV, Filip SVĚRÁK, Martin PEŠL, Jan PŘIBYL, Vladimír ROTREKL. hESC derived cardiomyocyte biosensor to detect the different types of arrhythmogenic properties of drugs. ANALYTICA CHIMICA ACTA, 2022, roč. 1216. ISSN 0003-2670. doi: 10.1016/j.aca.2022.339959.

2021

FRANEK, Michal, Agata Magdalena KILAR, Petr FOJTÍK, Marie OLSINOVÁ, Aleš BENDA, Vladimír ROTREKL, Martina DVOŘÁČKOVÁ, Jiří FAJKUS. Super-resolution microscopy of chromatin fibers and quantitative DNA methylation analysis of DNA fiber preparations. JOURNAL OF CELL SCIENCE, 2021, roč. 134. ISSN 0021-9533. doi: 10.1242/jcs.258374.

VRBSKÝ, Jan, Vladimir VINARSKÝ, Ana Rubina PERESTRELO, Jorge Oliver DE LA CRUZ, Fabiana MARTINO, Antonio POMPEIANO, Valerio IZZI, Ota HLINOMAZ, Vladimír ROTREKL, Marius SUDOL, Stefania PAGLIARI, Giancarlo FORTE. Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases. GENOMICS, 2021, roč. 113. ISSN 0888-7543. doi: 10.1016/j.ygeno.2021.03.009.

JELÍNKOVÁ, Šárka, Yvonne SLEIMAN, Petr FOJTÍK, Franck AIMOND, Amanda FINAN, Gerald HUGON, Valerie SCHEUERMANN, Deborah BECKEROVÁ, Olivier CAZORLA, Marie VINCENTI, Pascal AMEDRO, Sylvain RICHARD, Josef JAROŠ, Petr DVOŘÁK, Alain LACAMPAGNE, Gilles CARNAC, Vladimír ROTREKL, Albano C. MELI. Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, roč. 22. ISSN 1422-0067. doi: 10.3390/ijms22095025.

FOJTÍK, Petr, Deborah BECKEROVÁ, Kateřina HOLOMKOVÁ, Martin SENFLUK, Vladimír ROTREKL. Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells. FRONT CELL DEV BIOL, 2021, roč. 8. ISSN 2296-634X. doi: 10.3389/fcell.2020.607444.

SVOBODOVÁ, Barbora, Šárka JELÍNKOVÁ, Martin PEŠL, Deborah BECKEROVÁ, Alain LACAMPAGNE, A. C. MELI a Vladimír ROTREKL. Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. NEW YORK: SPRINGER, 2021, roč. 473, č. 7, s. 1099-1115. ISSN 0031-6768. doi:10.1007/s00424-021-02589-0.

SOUIDI, Monia, Yvonne Sleiman, Ivana ACIMOVIC, Jan PŘIBYL, Azzouz CHARRABI, Volker BAECKER, Valerie SCHEUERMANN, Martin PEŠL, Šárka JELINKOVÁ, Petr SKLADAL, Petr DVOŘÁK, Alain LACAMPAGNE, Vladimír ROTREKL, Albano C. MELI. Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids. Int. J. Mol. Sci, 2021, roč. 22, č. 2. eISSN 1422-0067. doi: 10.3390/ijms22020662.

2020

CALUORI, Guido, Eva ODEHNALOVÁ, Tomasz JADCZYK, Martin PEŠL, Iveta PAVLOVÁ, Lucia VALÍKOVÁ, Steffen HOLZINGER, Veronika NOVOTNÁ, Vladimír ROTREKL, Aleš HAMPL, Michal CRHA, Dalibor ČERVINKA a Zdeněk STÁREK. AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study. Frontiers in bioengineering and biotechnology, 2020, roč. 8, s. 1-14. ISSN 2296-4185. doi:10.3389/fbioe.2020.552357.

ŠTĚTKOVÁ, Monika, Kateřina GROWKOVÁ, Petr FOJTÍK, Barbora VALČÍKOVÁ, Veronika PALUŠOVÁ, Amandine VERLANDE, Radek JORDA, Vladimír KRYŠTOF, Václav HEJRET, Panagiotis ALEXIOU, Vladimír ROTREKL a Stjepan ULDRIJAN. CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells. CELL DEATH & DISEASE, 2020, roč. 11, č. 9, s. 1-14. ISSN 2041-4889. doi:10.1038/s41419-020-02971-3.

JELÍNKOVÁ, Šárka, Aleksandra VILOTIĆ, Jan PŘIBYL, Franck AIMOND, Anton SALYKIN, Ivana AĆIMOVIĆ, Martin PEŠL, Guido CALUORI, Šimon KLIMOVIČ, Tomáš URBAN, Hana DOBROVOLNÁ, Vladimír SOŠKA, Petr SKLÁDAL, Alain LACAMPAGNE, Petr DVOŘÁK, Albano C. MELI a Vladimír ROTREKL. DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology. Frontiers in bioengineering and biotechnology, 2020, roč. 8, s. 1-19. ISSN 2296-4185. doi:10.3389/fbioe.2020.00535.

PALUŠOVÁ, Veronika, Tereza RENZOVÁ, Amandine VERLANDE, Tereza VACLOVÁ, Michaela MEDKOVÁ, Linda CETLOVÁ, Miroslava SEDLÁČKOVÁ, Hana HŘÍBKOVÁ, Iva SLANINOVÁ, Miriama KRUTÁ, Vladimír ROTREKL, Hana UHLIROVA, Aneta KRIZOVA, Radim CHMELIK, Pavel VESELY, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Kay Oliver SCHINK a Stjepan ULDRIJAN. Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds. Cancers, 2020, roč. 12, č. 6, s. 1-24. ISSN 2072-6694. doi:10.3390/cancers12061516.

PEŠL, Martin, Šárka JELÍNKOVÁ, Guido CALUORI, Mária HOLICKÁ, Jan KREJČÍ, Petr NĚMEC, Aneta KOHUTOVÁ, Víta ŽAMPACHOVÁ, Petr DVOŘÁK a Vladimír ROTREKL. Cardiovascular progenitor cells and tissue plasticity are reduced in a myocardium affected by Becker muscular dystrophy. Orphanet Journal of Rare Diseases, 2020, roč. 2020, č. 65. doi:10.1186/s13023-019-1257-4.

2019

JELÍNKOVÁ, Šárka, Aneta KOHUTOVÁ, Petr FOJTÍK, Miriama KRUTÁ, Aleksandra VILOTIĆ, Martin PEŠL, Jan VRBSKÝ, Renata GAILLYOVÁ, Iveta VALÁŠKOVÁ, Ivan FRÁK, Giancarlo FORTE, Petr DVOŘÁK, Albano MELI, Vladimír ROTREKL, Lenka MARKOVÁ, Tereza JURÁKOVÁ a Alain LACAMPAGNE. Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress. Cells, Basel: MDPI, 2019, roč. 8, č. 1, s. 1-22. ISSN 2073-4409. doi:10.3390/cells8010053.

VÁŇOVÁ, Tereza, Jan RAŠKA, Pavel BABICA, Iva SOVADINOVÁ, Michaela BOSÁKOVÁ, Petr DVOŘÁK, Luděk BLÁHA a Vladimír ROTREKL. Freshwater Cyanotoxin Cylindrospermopsin Has Detrimental Stage-specific Effects on Hepatic Differentiation From Human Embryonic Stem Cells. Toxicological sciences, OXFORD: Academic Press, 2019, roč. 168, č. 1, s. 241-251. ISSN 1096-6080. doi:10.1093/toxsci/kfy293.

JELÍNKOVÁ, Šárka, Lenka MARKOVÁ, Martin PEŠL, Iveta VALÁŠKOVÁ, Eva MAKATUROVÁ, Lenka JUŘÍKOVÁ, Petr VONDRÁČEK, Alain LACAMPAGNE, Petr DVOŘÁK, Albano MELI a Vladimír ROTREKL. Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A). STEM CELL RESEARCH, AMSTERDAM: ELSEVIER, 2019, roč. 40, OCT 2019, s. 1-5. ISSN 1873-5061. doi:10.1016/j.scr.2019.101562.

KOHUTOVÁ, Aneta, Jan RAŠKA, Miriama KRUTÁ, Monika ŠENEKLOVÁ, Tomáš BÁRTA, Petr FOJTÍK, Tereza JURÁKOVÁ, Christi A. WALTER, Aleš HAMPL, Petr DVOŘÁK a Vladimír ROTREKL. Ligase 3-mediated end-joining maintains genome stability of human embryonic stem cells. Faseb Journal, BETHESDA: FEDERATION AMER SOC EXP BIOL, 2019, roč. 33, č. 6, s. 6778-6788. ISSN 0892-6638. doi:10.1096/fj.201801877RR.

CALUORI, Guido, Jan PŘIBYL, Martin PEŠL, Šárka JELÍNKOVÁ, Vladimír ROTREKL, Petr SKLÁDAL a Roberto RAITERI. Non-invasive electromechanical cell-based biosensors for improved investigation of 3D cardiac models. Biosensors & bioelectronics : the international journal for the professional involved with research, technology and applications of biosensors and related devices, Elsevier Science, 2019, roč. 124, JAN 15 2019, s. 129-135. ISSN 0956-5663. doi:10.1016/j.bios.2018.10.021.

CALUORI, Guido, Jan PŘIBYL, Vratislav CMIEL, Martin PEŠL, Tomas POTOCNAK, Ivo PROVAZNÍK, Petr SKLÁDAL a Vladimír ROTREKL. Simultaneous study of mechanobiology and calcium dynamics on hESC-derived cardiomyocytes clusters. Journal of Molecular Recognition, Hoboken: Wiley, 2019, roč. 32, č. 2, s. 1-9. ISSN 0952-3499. doi:10.1002/jmr.2760.

All publications back to 1996