ONGOING RESEARCH SUPPORT

2025-2027: Czech Science Foundation; GA25-17326S; PI; 8 703 ths CZK; Structural characterisation of RAD51-G4 complex and its biological role.

2024-2026: H2020; 101158508; Co-PI; 397 ths EUR (for the whole project 1 200 ths EUR); TRIAD: Enhancing Synergism on Telomere Function in Health and Disease.

2021-2025: Czech Science Foundation; GACR 21-22593X; PI; 49 901 ths CZK; Identification and characterization of proteins involved in metabolism of G-quadruplexes and R-loops and molecular mechanisms of their relationship with replication.

COMPLETED RESEARCH SUPPORT

2019-2023: H2020; 812829; Co-PI; 234 ths EUR (for the whole project 3 789 ths EUR); aDDRess - Joint Training and Research Program on Chromatin Dynamics and the DNA Damage Response.

2017-2023: Wellcome Trust - Collaborative Award in Science; 206292/E/17/Z; Co-PI; 15 079 ths CZK; Mechanics and execution of homologous recombination - biophysics to the organism.

2020-2023: Masaryk University / Research support program, MUNI/G/1594/2019; PI; 1 796 ths CZK; RecQ4 – a protein hub required for proper replication and recombination and its implications in Rothmund-Thomson Syndrome.

2018-2022: EF – OP VVV(2014 - 2020); EF16_025/0007381; Ministry of Education of the Czech Republic; Co-PI; 98 640 ths CZK; Preclinical Progression of New Organic Compounds with Targeted Biological Activity.

8/17/2017: signed collaboration agreement with the UK-based company Artios Pharma Ltd. on the development of nuclease inhibitors: http://www.artiospharma.com/news-events/; Co-PI; 43 712 ths CZK

2016-2020: National Sustainibility Programme II (Ministry of Education of the Czech Republic); LQ1605; Co-PI; 1 731 165 ths CZK; Translation medicine.

2017-2019: TA ČR Gama; TG02010048

• Identification and characterization of low molecular weight XPF / ERCC1 nuclease inhibitors; CO-PI; 1 797 ths CZK
• Preclinical progression of MRE11 inhibitors as new specific antitumor agents; CO-PI; 1 691 ths CZK

2017-2019: Czech Science Foundation; GAČR 17-17720S; PI; 8 900 ths CZK; Intrinsic properties of RAD51 filament and its biological regulations.

2015-2018: Ministry of Health of the CR / Ministry of Health Research Programme; 15-33999A; Co-PI; 16 815 ths CZK; Development of novel small molecules anticancer compounds with synthetic lethal effect.

2015-2017: Masaryk University / Research support program; MUNI/M/1894/2014; PI; 4 999 ths CZK; Development of new MUS81 nuclease inhibitors as chemical biology probe with clinical progression.

2013-2017: Czech Science Foundation; GAČR 13-26629S; PI; 15 674 ths CZK; SUMO and genome stability.

2013-2016: FP7 - 7th Framework Programme for Research and Development; 316345; Co-PI; 4 497 ths EUR; Human Bridge for Strengthening Integration of ICRC into European Research Area (ICRC-ERA Human Bridge).

20012-2016: Czech Science Foundation;, GAČR 207/12/2323; Co-PI; 14 931 ths CZK; Endonuclease and translocase activity in type I restriction-modification complexes.

2012-2014: Ministry of Education of the Czech Republic; EE2.3.20.0011; Co-PI; 35 645 ths CZK; Centre for pluripotent cells and genome instability research (PLURICELL).

2009-2012: Ministry of Education of the Czech Republic; CZ.1.07/2.3.00/09.0186; Co-PI; 19 700 ths CZK; Mendel center for education in biology and biomedicine.

2008-2011: FP7 - 7th Framework Programme for Research and Development; Regpot; 205872; Co-PI; 1 050 ths EUR; Program developing interdisciplinary research potential for the studies of biomolecular interactions (POSTBIOMIN).

2010-2012: American Science Information Center, Ministry of Education of the Czech Republic; TAČR; ME10048; PI; 1 632 ths CZK; The roles of post-translational protein modification during DNA repair and recopmbination.

2009-2012: Czech Science Foundation; GAČR 203/09/H046; Co-PI; 11 993 ths CZK; Biochemistry on the crossroad between in silico and in vitro.

2009-2011: Czech Science Foundation; GAČR 301/09/1917; PI; 4 013 ths CZK; Resolution of replication-recombination DNA intermediates and its role in genomic instability.

2006-2012: Welcome International Science Fellowship (WT076476); PI; 24 000 ths CZK; Role of BRCA2 in Homologous Recombination and Genome Maintenance.

2006-2011: Ministry of Education of the Czech Republic; TAČR; LC06030; Co-PI; 62 470 ths CZK; Biomolecular Centre.

2005-2011: Ministry of Education of the Czech Republic; MSM0021622413; Co-PI; 250 ths CZK; Proteins in metabolism and interaction of organisms with the environment.

2006-2008: ME - KONTAKT (1996 - 2012) ME 888; 6 586 ths CZK; Srs2 protein and its multi-functional role in recombination/repair processes.

2006-2008: EMBO/HHMI Startup grant; 0,2 ths EUR; Srs2 protein and its multi-functional role in recombination/repair processes.

2003-2006: US DOD Postdoctoral Fellowship BC020457; 2 ths USD; Role of Rad51-mediated Interactions in Recombination.

2001: NATO Science Fellowship Program; PI; Function of human Rad51 paralogs in homologous recombination.