2025

• Discovery of new inhibitors of nuclease MRE11

  NIKULENKOV Fedor CARBAIN Benoit Jean-Pierre BISWAS Raktim HAVEL Štěpán PROCHÁZKOVÁ Jana SISÁKOVÁ Alexandra ZACPALOVÁ Magdaléna CHAVDAROVA Melita MARINI PALOMEQUE María Victoria VŠIANSKÝ Vít WEISOVÁ Veronika SLÁVIKOVÁ Kristína BIRADAR Dhanraj Omprakash KHIRSARIYA PrashantKumar VITEK Marco SEDLAK David BARTUNEK Petr DANIEL Lukáš BREZOVSKÝ Jan DAMBORSKÝ Jiří PARUCH Kamil KREJČÍ Lumír

  Article in Periodical

  European Journal of Medicinal Chemistry, year: 2025, volume: 285, edition: March, DOI

• RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome

  ASHRAF Raghib POLÁŠEK-SEDLÁČKOVÁ Hana MARINI María Victoria PROCHÁZKOVÁ Jana HAŠANOVÁ Zdenka ZACPALOVÁ Magdaléna BOUDOVÁ Michala KREJČÍ Lumír

  Article in Periodical

  Nature Communications, year: 2025, volume: 16, edition: 1, DOI

2024

• Concurrent D-loop cleavage by Mus81 and Yen1 yields half-crossover precursors

  CARREIRA Raquel LAMA-DIAZ Tomas CRUGEIRAS Maria AGUADO F Javier ŠEBESTA Marek KREJČÍ Lumír BLANCO Miguel G

  Article in Periodical

  Nucleic Acids Research, year: 2024, volume: 52, edition: 12, DOI

• Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA

  AKITA Masaki GIRVAN Paul ŠPÍREK Mário NOVÁČEK Jiří RUEDA David PROKOP Zbyněk KREJČÍ Lumír

  Article in Periodical

  Nucleic Acids Research, year: 2024, volume: 52, edition: 19, DOI

• MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops

  ISIK Esin SHUKLA Kaustubh POSPÍŠILOVÁ Michaela KÖNIG Christiane ANDRS Martin RAO Satyajeet ROSANO Vinicio DOBROVOLNA Jana KREJČÍ Lumír JANSCAK Pavel

  Article in Periodical

  Science advances, year: 2024, volume: 10, edition: 6, DOI

• Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity

  AITHAL Rakesh NANGALIA Kuldeep ŠPÍREK Mário CHEN Doris KLEIN Franz KREJČÍ Lumír

  Article in Periodical

  Nucleic acids research, year: 2024, volume: 52, edition: 8, DOI

• RAD51 separation of function mutation maintenance but preserves DSB repair

  SON Mi Young BELÁŇ Ondrej ŠPÍREK Mário CIBULKA Jakub NIKULENKOV Fedor KIM You Young HWANG Sunyoung MYUNG Kyungjae MONTAGNA Cristina KIM Tae Moon KREJČÍ Lumír HASTY Paul

  Article in Periodical

  iScience, year: 2024, volume: 27, edition: 4, DOI

2023

• MUS81 cleaves TOP1‑derived lesions and other DNA-protein cross‑links

  MARINI PALOMEQUE María Victoria NIKULENKOV Fedor SAMADDER Pounami JUUL Sissel KNUDSEN Birgitta R. KREJČÍ Lumír

  Article in Periodical

  BMC Biology, year: 2023, volume: 21, edition: 1, DOI

• Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase

  PAPAGEORGIOU Anna POSPÍŠILOVÁ Michaela CIBULKA Jakub ASHRAF Raghib WAUDBY Christopher KADEŘÁVEK Pavel MAROZ Volha KUBÍČEK Karel PROKOP Zbyněk KREJČÍ Lumír TRIPSIANES Konstantinos

  Article in Periodical

  Nature Communications, year: 2023, volume: 14, edition: 1, DOI

2022

• The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination

  ALTMANNOVÁ Veronika ŠPÍREK Mário ORLIC Lucija JEKABSONS Atis CLARENCE Tereza HENGGELER Adrian MLCOUSKOVA Jarmila CHALEIL Raphael A G MATOS Joao KREJČÍ Lumír

  Article in Periodical

  iSCIENCE, year: 2022, volume: 25, edition: 11, DOI